Financial Secretary Paul Chan will visit Hangzhou from May 14 to 16.
He will officiate at the opening ceremony of SmartHK 2018 held by the Hong Kong Trade Development Council.
He will witness the signing of a memorandum of understanding on co-operation between the council and the Hangzhou Municipal Government.
Mr Chan will also meet Zhejiang Province officials, visit enterprises from emerging and innovative sectors, and meet Hong Kong people doing business there.
Secretary for Financial Services & the Treasury James Lau will be Acting Financial Secretary during Mr Chan's absence.